Harang's four innings matched the total he pitched in emergency relief in an 18-inning Reds game at San Diego on Sunday. That outing clearly affected him. The right-hander allowed six earned runs and 10 hits with two strikeouts.

Most of the Pittsburgh damage came in the third and fourth innings. In the third, Harang gave up three doubles, including RBI two-baggers by Xavier Nady and Jason Michaels. In the three-run fourth, Jason Bay hit a two-run homer to left field.

In the fifth with Jeremy Affeldt on in relief of Harang, leadoff batter Nady drilled a first-pitch offering for a home run to right field.

Former Red Phil Dumatrait turned in a superb start for the Pirates. Dumatrait allowed just one unearned run and two hits over seven innings, while striking out nine. Last season in six starts for the Reds, the lefty was 0-4 with a 15.00 ERA.

The Reds' only run scored in the first inning. With one out and runners on first, the Pirates tried to turn a double play on Brandon Phillips' groundball to shortstop but Freddy Sanchez's relay throw sailed into the first base dugout for an error that scored Jerry Hairston Jr.

Cincinnati's nine-game home winning streak, including the first two games of the Pittsburgh series, was snapped with the defeat.